5-Amino-1MQ 50mg (60 Capsules)
$255.00
5-amino-1MQ is a small-molecule research compound that functions as a selective nicotinamide N-methyltransferase (NNMT) inhibitor. In preclinical metabolic models, it enhances NAD⁺ salvage pathway flux, leading to improved energy homeostasis and sirtuin activation. 5-Amino-1MQ is used to investigate epigenetic and redox control mechanisms associated with cellular metabolism and aging.
References:
Kraus D et al., Nat Commun, 2014;5:4113
Kannt A et al., Biochem Pharmacol, 2018;155:316–328
Ulanovskaya OA et al., Nat Chem Biol, 2013;9(5):300–306
These capsules are provided exclusively as inert containers for the dry transport, storage, and handling of laboratory research materials. They are not dosage forms and are not intended for ingestion or administration. They must not be used as drug delivery systems, consumed, or administered in any form. For Research Use Only: Not for use in humans or animals. Not for diagnostic or therapeutic purposes.
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Product Overview
5-Amino-1MQ 50mg (60 Capsules) is a premium research compound widely utilized in various scientific studies.
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This compound has been studied extensively for its unique biochemical properties and its role in cellular pathways.
Overview
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule methylquinolinium compound described in scientific literature as an experimental modulator of nicotinamide N-methyltransferase (NNMT)–associated biochemical pathways. NNMT is an intracellular enzyme involved in nicotinamide metabolism and methylation-dependent cellular processes.
Published studies referencing 5-Amino-1MQ describe its use exclusively within laboratory-based experimental systems, including cellular assays and animal research models. All observations are limited to non-clinical research contexts.
No claims regarding therapeutic use, clinical efficacy, or human application are made.
Biochemical Characteristics
5-Amino-1MQ is classified as a membrane-permeable small molecule with documented interactions involving nicotinamide metabolism and NNMT-linked methylation pathways. NNMT participates in the conversion of nicotinamide to methylated metabolites, influencing intracellular NAD balance, methyl donor availability, and metabolic flux in experimental systems.
Biochemical investigations describe NNMT as a regulator of cellular energy handling, redox balance, and methylation-dependent signaling networks. Observations involving 5-Amino-1MQ are confined to enzymatic and molecular studies conducted in controlled research models.
Molecular Formula: C10H11N2
Molecular Weight: 159.21 g/mol
PubChem CID: 950107
CAS Number: 42464-96-0
Reported Synonyms: 5-amino-1-methylquinolinium
Source: PubChem
Research Applications
In the scientific literature, 5-Amino-1MQ has been utilized as an experimental research compound to investigate NNMT-associated metabolic pathways and downstream cellular responses in non-clinical models.
- NNMT-mediated nicotinamide methylation pathways
- NAD -associated metabolic regulation
- Cellular energy utilization and metabolic flux dynamics
- GLUT4-associated glucose transport signaling (experimental context)
- Stem cell–related transcriptional markers in model systems
All applications remain restricted to controlled laboratory research environments.
Pathway / Mechanistic Context
Mechanistic discussions describe 5-Amino-1MQ in relation to NNMT-linked regulation of intracellular nicotinamide pools, methyl donor balance, and NAD -dependent enzymatic pathways. These processes have been examined in cellular and animal models to characterize shifts in metabolic efficiency and transcriptional signaling.
Additional experimental observations reference interactions with mitochondrial function, oxidative stress–associated pathways, and stem cell signaling networks. All mechanistic descriptions remain observational and confined to preclinical research systems.
Preclinical Research Summary
Preclinical publications describe 5-Amino-1MQ-associated observations in rodent and cellular models involving metabolic flux, adipose and muscle tissue signaling markers, and NNMT-regulated transcriptional profiles.
Additional experimental studies have examined NNMT expression in relation to cellular proliferation, stem cell activation markers, and cancer-associated metabolic phenotypes. These findings are strictly limited to experimental research models and do not imply clinical relevance.
Form & Analytical Testing
5-Amino-1MQ is supplied as a research-grade small-molecule material. Identity and purity are evaluated using standard analytical methodologies applicable to small-molecule research, including chromatographic separation and mass spectrometric characterization.
Referenced Citations
- Neelakantan H. et al., “Selective and membrane-permeable small-molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice,” Biochem Pharmacol, 2018.
- Pissios P., “Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme,” Trends Endocrinol Metab, 2017.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
RUO Disclaimer
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
For Laboratory Research Only. Not for human use, medical use, diagnostic use, or veterinary use.
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Specifications & Technical Data
| Feature | Specification |
|---|---|
| Product Name | 5-Amino-1MQ 50mg (60 Capsules) |
| SKU | 1 |
| Purity | >99% |
| Form | Research Grade Compound |
| Availability | In Stock / For Sale |
Scientific Research & Clinical Applications
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For more detailed scientific data, you can visit PubMed
to review the latest peer-reviewed literature regarding this compound.
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